Semi-synthesis technologies

Chemical processes

  • Doxorubicin from daunomycin
  • Epirubicin from daunomycin
  • Idarubicin from daunomycin
  • Cabergoline from lysergic acid
  • Nicergoline from lysergic acid
  • Minocycline from demeclocycline
  • Amikacin form kanamycin
  • Azythromycin form erythromycin A
  • Chlarithromycin from erythromycin A
  • Clindamycin from lincomycin
  • Amoxicillin from 6-APA
  • Ampicillin from 6-APA
  • Sulbactam from 6-APA
  • Sulbactam from penicillin G K
  • Cefatrizine from 7-ACA
  • Cefotaxime from 7-ACA
  • Ceftriaxone from 7-ACA
  • Cefuroxime from 7-ACA
  • ephalotin from 7-ACA
  • Cephadroxil from 7-ADCA
  • Cephradine HCl from 7-ADCA
  • Cephradine from Cephradine HCl
  • Cephaloridine from Cephradine
  • Canrenone from 4-androstene-3,17-dione
  • Spironolactone from 4-androstene-3,17-dione
  • Ranitidine form 1 from furfuril alcohol
  • Simvastatin from lovastatin
  • Thiamulin fumarate from pleuromutilin

 

Enzymatic processes

  • 6-APA, 6-amino-penicillanic acid from penicillin G
  • 7-ACA, 7-amino-cephalosporanic acid from cephalosporin C
  • 7-ADCA, 7-amino-deacetoxycephalosporanic acid penicillin G
  • Amoxicillin from 6-APA
  • Cefazolin from 7-ACA
  • Cephalexin from 7-ADCA
  • D-(-)-a-p-hydroxyphenylglycine (chemical plus enzymatic)
  • D-aminoacids (alanine, serine, phenylalanine, p-Cl-phenylalanine)
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