TECHNOLOGIES | Semi-synthesis technologies

Chemical processes

Doxorubicin from daunomycin
Epirubicin from  daunomycin
Idarubicin from daunomycin

Cabergoline from lysergic acid
Nicergoline from lysergic acid

Minocycline from demeclocycline

Amikacin form kanamycin

Azythromycin form erythromycin A
Chlarithromycin from erythromycin A

Clindamycin from lincomycin

Amoxicillin from 6-APA
Ampicillin from 6-APA
Sulbactam from 6-APA
Sulbactam from penicillin G K

Cefatrizine from 7-ACA
Cefotaxime from 7-ACA
Ceftriaxone from 7-ACA
Cefuroxime from 7-ACA
Cephalotin from 7-ACA

Cephadroxil from 7-ADCA
Cephradine HCl from 7-ADCA
Cephradine from Cephradine HCl
Cephaloridine from Cephradine

Canrenone from 4-androstene-3,17-dione
Spironolactone from 4-androstene-3,17-dione

Ranitidine form 1 from furfuril alcohol
Simvastatin from lovastatin
Thiamulin fumarate from pleuromutilin

Enzymatic processes

6-APA, 6-amino-penicillanic acid from penicillin G
7-ACA, 7-amino-cephalosporanic acid from cephalosporin C
7-ADCA, 7-amino-deacetoxycephalosporanic acid penicillin G
Amoxicillin from 6-APA
Cefazolin from 7-ACA
Cephalexin from 7-ADCA

D-(-)-a-p-hydroxyphenylglycine (chemical plus enzymatic)
D-aminoacids (alanine, serine, phenylalanine, p-Cl-phenylalanine)